In 1885, while still struggling to make it as a writer, Doyle met and married his first wife, Louisa Hawkins. The couple moved to Upper Wimpole Street and had two children, a daughter and a son. In 1893, Louisa was diagnosed with tuberculosis. While Louisa was sick, Doyle developed an affection for a young woman named Jean Leckie. Louisa ultimately died of tuberculosis in Doyle's arms, in 1906. The following year, Doyle would remarry to Jean Leckie, with whom he would have two sons and a daughter.